Alcohol and reward
Alcohol can repeatedly activate the brain's reward pathways. Over time, that learned association can make urges feel automatic and difficult to ignore.
A free 15-minute call gives you space to ask about the programme. It is not a prescription appointment. Medical suitability, prescribing and any need for withdrawal support are assessed by a doctor.
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Naltrexone is a prescription medicine that may be considered for adults who want to change their relationship with alcohol. Under The Sinclair Method, it is used in a targeted way alongside clinical oversight, practical guidance and consistent support.
Medication is not provided as a standalone service. Every person starts with a suitability conversation and, if appropriate, a private assessment with a UK-registered prescribing clinician.
Clinical treatment. Any medication is considered only after a clinician has assessed your individual suitability.
The Sinclair Method works with the brain's learned response to alcohol. It does not rely on suddenly stopping through willpower alone.
Alcohol can repeatedly activate the brain's reward pathways. Over time, that learned association can make urges feel automatic and difficult to ignore.
Naltrexone blocks opioid receptors involved in alcohol's reward response. When used correctly, it can reduce the reinforcement that keeps the learned loop going.
With consistency, the association between alcohol and reward may weaken. Progress varies, so your clinician and coach help you understand and track what is changing.
Read more: Naltrexone explained in more detail · A beginner’s guide to the Sinclair Method
The prescription does not sit on its own. The programme gives you a clear process and a team to turn to throughout.

SMUK offers a programme of assessment, coaching and practical learning around treatment, rather than a prescription-only service. Discuss what level of support you need before choosing a provider.
See full programme prices · How personal information is handled
We are a private service. We do not routinely tell your GP or employer about your treatment. We would seek your consent before sharing information, unless disclosure is required by law or necessary to protect someone from serious harm. You can ask us about confidentiality before you book.
Our coaches are trained in the method by Dr Roy Eskapa.
A 15-minute conversation with a senior coach. Ask questions, explain what you want to change and decide whether to go further.
If you choose to go ahead, a UK-registered doctor reviews your health and medicines and decides whether treatment is suitable.
If prescribed, arrange your medication with the dispensing pharmacy. Medication is paid for separately from the programme.
Your coaching, practical learning and private community help you work through your programme.
Onboarding is usually within 48 hours, subject to suitability, your availability and clinical availability.
Naltrexone is not suitable for everyone. Your clinician will review your medical history, liver health, current medicines and any use of opioid pain relief before deciding whether it can be prescribed.
We provide an integrated clinical and coaching programme. Correct timing, consistency, progress review and support are all important parts of The Sinclair Method.
Yes. A UK-registered prescribing clinician must assess whether it is medically suitable for you before a prescription can be issued.
No. Medication is not provided as a standalone service. When clinically appropriate, it forms one part of an integrated programme with guidance, monitoring and coaching support.
The Sinclair Method is not an abrupt abstinence programme. Your clinician will explain how the targeted protocol is used. If you may be physically dependent, never stop suddenly without medical advice.
There is no fixed timeline and no treatment can guarantee a particular result. Progress is usually gradual, which is why consistency and honest tracking are important.
No. Suitability depends on your health, medicines and individual circumstances. The clinical assessment is the decision point, and alternatives will be discussed if it is not appropriate.
Book a 15-minute introduction call to understand the programme and ask general questions before deciding whether to proceed.
This page provides general information and does not replace individual medical advice.